A benzene ring-containing compound, a preparation method therefor and an application thereof. Specifically provided are a compound represented by formula (I-0), a pharmaceutically acceptable salt thereof, a solvate thereof, a metabolite thereof, a stereoisomer thereof, a tautomer thereof or a prodrug thereof. The compound may be used as an immunomodulator, which exhibits the advantages of high activity, good drug efficacy, drug stability, and being able to be combined with other immunomodulators.