专利名称 | NOVEL BENZIMIDAZOLONE COMPOUND AND PHARMACEUTICAL USE THEREOF | ||
申请号 | EP18768087 | 申请日 | |
公开(公告)号 | EP3597640A1 | 公开(公告)日 | |
申请(专利权)人 | Sumitomo Dainippon Pharma Co Ltd | 发明人 | MIZUSHIMA Shingo; WATANABE Masaki; IWAMOTO Kohei; URASHIMA Kuniko |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present invention relates to a medicament for treating or preventing a disease involving Nav 1.7, specifically such neuropathic pain, nociceptive pain, inflammatory pain, small-fiber neuropathy, erythromelalgia, paroxysmal extreme pain disorder, dysuria, and multiple sclerosis, comprising a compound of formula (I) wherein R1a, R1b, R1c, and R1d are hydrogen, halogen, cyano, C1-4 alkyl, C1-4 alkoxy, etc., provided that at least one of R1a, R1b, R1c and R1d is the above C6-10 aryl, C6-10 aryloxy, etc., R2 and R3 are hydrogen, C1-6 alkyl, C3-10 cycloalkyl, etc., R4 is hydrogen, C1-6 alkyl, C3-4cycloalkyl, etc., m is 0, 1, 2, or 3, L is CR7R8, R7 and R8 are hydrogen, hydroxy group, C1-4 alkyl, C1-4 alkoxy, etc., or a pharmaceutically acceptable salt thereof. |
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