| 专利名称 | Live-Attenuated Vaccine Having Mutations in Viral Polymerase for the Treatment and Prevention of Canine Influenza Virus | ||
| 申请号 | US16589247 | 申请日 | |
| 公开（公告）号 | US20200023055A1 | 公开（公告）日 | |
| 申请（专利权）人 | University of Rochester; Cornell University | 发明人 | Luis Martinez Sobrido; Aitor Nogales Gonzalez; Colin Parrish |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
The present invention relates to compositions and methods for the treatment and prevention of canine influenza virus (CIV) and CIV-related pathology. The present invention is based in part upon the discovery that various mutations in segment 1 and segment 2 of the CIV genome, thereby encoding mutant PB2 and PB1 protein, render the virus to be temperature-sensitive. |
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