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专利概况
专利名称 CREATING CONTROLLED RELEASE PROFILE OF DRUG SUBSTANCE USING LIPOSOMAL COMPOSITION IN AQUEOUS AND ANHYDROUS SOLUTIONS
申请号 RU2015135629 申请日
公开(公告)号 RU2712157C2 公开(公告)日
申请(专利权)人 TAJVAN LIPOSOM KOMPANI ELTEDE 发明人 KAN PEI; TSENG YUN LONG; OU HAN CHUN
专利来源 国家知识产权局 转化方式
摘要

FIELD : medicine; pharmaceuticals.SUBSTANCE : group of inventions refers to pharmaceutical industry, in particular to embodiments of a pharmaceutical composition for inhibiting growth of cancer cells. In one embodiment, the composition includes a component which forms a particle selected from a phospholipid and a mixture of at least one phospholipid and cholesterol; 0.1–10 mM dextran sulphate ion or its pharmaceutically acceptable salt; 100–500 mM ammonium sulphate; amphipathic therapeutic agent or its pharmaceutically acceptable salt. In another embodiment of the composition, the amount of ammonium sulphate is 150–450 mM, and the amphipathic therapeutic agent is a vinca roseacola alkaloid. Also disclosed are : a liposome for delivering an amphipathic therapeutic agent and a method of inhibiting growth of cancer cells by administering an effective amount of said pharmaceutical composition.EFFECT : group of inventions provides optimal therapeutic effectiveness and reduced toxic effect on skin.16 cl, 4 dwg, 11 tbl, 10 ex

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