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专利概况
专利名称 PYRROLO[2, 3-D]PYRIMIDINE COMPOUND OR SALT THEREOF
申请号 RU2018103360 申请日
公开(公告)号 RU2712269C2 公开(公告)日
申请(专利权)人 ТАЙХО ФАРМАСЬЮТИКАЛ КО ЛТД; TAIHO PHARMACEUTICAL CO LTD 发明人 НАКАМУРА Масаюки; НАКАМУРА МасаюкиNAKAMURA Masayuki; ЯМАНАКА Хироёси; ЯМАНАКА ХироёсиYAMANAKA Hiroyoshi; МИЦУЯ Морихиро; МИЦУЯ МорихироMITSUYA Morihiro; ХАРАДА Такафуми; ХАРАДА ТакафумиHARADA Takafumi
专利来源 国家知识产权局 转化方式
摘要

FIELD : medicine; pharmaceuticals.SUBSTANCE : invention relates to a new compound of formula (I) or a pharmaceutically acceptable salt thereof. Compound has the properties of a selective JAK3 inhibitor, exhibits high activity in suppressing the growth of human peripheral blood monocytes and oral absorption, and also exhibits activity when inhibiting IFN-γ in vivo. In general formula (I)X is -CH = CH-, sulphur atom or oxygen atom; and n denotes integer from 0 to 2.EFFECT : compound can be used for treating diseases involving JAK3, where the disease involving JAK3 is selected from a group consisting of psoriasis, graft versus host, multiple sclerosis, inflammatory bowel disease, systemic lupus erythematosus and rheumatoid arthritis.16 cl, 2 dwg, 5 tbl, 31 ex

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