专利 - 详情

专利名称	METHOD OF PRODUCING AN ANTIOXIDANT AGENT IN THE FORM OF A TABLET WITH PROLONGED EFFECT
申请号	RU2019117278	申请日
公开（公告）号	RU2712445C1	公开（公告）日
申请（专利权）人	Закрытое акционерное общество "ОБНИНСКАЯ ХИМИКО ФАРМАЦЕВТИЧЕСКАЯ КОМПАНИЯ"; Zakrytoe aktsionernoe obshchestvo "OBNINSKAYA KHIMIKO FARMATSEVTICHESKAYA KOMPANIYA"	发明人	Исмагилов Искандар Халиуллович; Исмагилов Искандар ХалиулловичIsmagilov Iskandar Khaliullovich; Фазылов Марат Феликсович; Фазылов Марат ФеликсовичFazylov Marat Feliksovich; Пучнин Владимир Сергеевич; Пучнин Владимир СергеевичPuchnin Vladimir Sergeevich; Кулаева Лариса Васильевна; Кулаева Лариса ВасильевнаKulaeva Larisa Vasilevna; Закиров Марат Рашидович; Закиров Марат РашидовичZakirov Marat Rashidovich; Моисеева Светлана Михайловна; Моисеева Светлана МихайловнаMoiseeva Svetlana Mikhajlovna
专利来源	国家知识产权局	转化方式
摘要	FIELD : medicine; pharmaceutics.SUBSTANCE : invention refers to chemical-pharmaceutical industry and medicine. Disclosed is a method of producing an antioxidant agent in the form of prolonged release, characterized in that a sifted mixture of ethyl methylhydroxypyridine succinate and hydroxypropyl methyl cellulose with viscosity of 2, 700–5, 040 MPa?with is mixed with a previously obtained moistening agent, which is an aqueous solution of hydroxypropyl methyl cellulose with viscosity of 4.8–7.2 mPa?s, the mixture is granulated in boiling (fluidized) layer; obtained granules are powdered with magnesium stearate and silicon with colloidal dioxide, subjected to dry granulation with subsequent pressing into tablets and film coating.EFFECT : tablets have an improved pharmacological release profile.4 cl, 1 tbl, 2 ex 1人已参与 0数据匹配