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专利概况
专利名称 METHOD FOR SAFELY PREPARING PIMAVANSERIN AND TARTRATE SALT THEREOF USING TRIPHOSGENE
申请号 WOCN19096705 申请日
公开(公告)号 WO2020020064A1 公开(公告)日
申请(专利权)人 LIVZON NEW NORTH RIVER PHARMACEUTICAL CO LTD 发明人 JIANG Qiao; LI Bingbing; PENG Murong; XIE Weijian
专利来源 国家知识产权局 转化方式
摘要

Disclosed in the present invention is a method for safely preparing pimavanserin and a tartrate salt thereof using triphosgene. The synthesis routes comprise (1), (2), (3), (4) and (5). The raw materials used in the method of the present invention are safe, and have low cost, effectively reducing the production cost. The reaction conditions of the method of the present invention are mild, the use of phosgene, having high toxicity and being difficult to operate, can be avoided, and the method is easy to implement industrially.

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