FIELD : medicine; biotechnology.SUBSTANCE : invention refers to biotechnology and medicine, particularly to a technology of conjugates of an antibody with a drug. Disclosed is a compound of chemical formula 1 : , including a self-splitting group, an antibody having substrate-specificity with respect to the target, and a drug. Linker L is a linker linking A and W of the self-splitting group by covalent bonds and includes at least one link which is an isoprenyl derivative : , which is recognized by isoprenoid transferase.EFFECT : disclosed compounds have high plasma stability and enable the drug to be easily released in the target cells for drug exposure.22 cl, 22 dwg, 6 tbl, 20 ex