| 专利名称 | Methods for the preparation of obeticholic acid and derivatives thereof | ||
| 申请号 | US16094535 | 申请日 | |
| 公开（公告）号 | US10550146B2 | 公开（公告）日 | |
| 申请（专利权）人 | Intercept Pharmaceuticals Inc | 发明人 | Benjamin List; Chandra Kanta De; Qinggang Wang |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
The present application relates to a safe method of preparing a bile acid derivative or a pharmaceutical acceptable salt, solvate, or amino acid conjugate thereof, on a large scale from 7-keto lithocholic acid (KLCA), comprising reacting Compound 2 with paraldehyde to form Compound 3 at a temperature between 10?C. and 30?C. : |
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