The invention provides a traditional Chinese medicine composition for the control of blood lipids and/or weight of body, which includes Poria and Paeoniae Radix Alba, etc. the traditional Chinese medicine composition can be applied in reducing the total cholesterol level, triacylglycerol level, and low density lipoprotein cholesterol level in the body; increasing body high density lipoprotein cholesterol level, reducing uric acid level, and/or reducing symptoms of fatty liver. The invention also provides preparation methods and applications of this traditional Chinese medicine composition.