| 专利名称 | FLUORINATED BILE ACID DERIVATIVES | ||
| 申请号 | WOGB19052127 | 申请日 | |
| 公开(公告)号 | WO2020025942A1 | 公开(公告)日 | |
| 申请(专利权)人 | NZP UK LIMITED; THE UNIVERSITY OF SOUTHAMPTON | 发明人 | WEYMOUTH WILSON Alexander Charles; PACKER Gemma; LINCLAU Bruno Jan Pol; KYDD SINCLAIR Dannielle; WATSON Kimberly Ann |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
Compounds of general formula (I) : wherein R2a, R2b, R3a, R3b, R5, Y and R7 are as defined herein are selective agonists at the FXR receptor and are useful for the treatment or prevention of diseases and conditions including nonalcoholic steatohepatitis (NASH); primary biliary cirrhosis; primary sclerosing cholangitis; biliary atresia; cholestatic liver disease; hepatitis C infection; alcoholic liver disease; fibrosis; or liver damage arising from fibrosis. |
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