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专利概况
专利名称 FLUORINATED BILE ACID DERIVATIVES
申请号 WOGB19052127 申请日
公开(公告)号 WO2020025942A1 公开(公告)日
申请(专利权)人 NZP UK LIMITED; THE UNIVERSITY OF SOUTHAMPTON 发明人 WEYMOUTH WILSON Alexander Charles; PACKER Gemma; LINCLAU Bruno Jan Pol; KYDD SINCLAIR Dannielle; WATSON Kimberly Ann
专利来源 国家知识产权局 转化方式
摘要

Compounds of general formula (I) : wherein R2a, R2b, R3a, R3b, R5, Y and R7 are as defined herein are selective agonists at the FXR receptor and are useful for the treatment or prevention of diseases and conditions including nonalcoholic steatohepatitis (NASH); primary biliary cirrhosis; primary sclerosing cholangitis; biliary atresia; cholestatic liver disease; hepatitis C infection; alcoholic liver disease; fibrosis; or liver damage arising from fibrosis.

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