| 专利名称 | CRYSTALLINE FORM OF JAK KINASE INHIBITOR BISULFATE AND A PREPARATION METHOD THEREOF | ||
| 申请号 | HRP20192030 | 申请日 | |
| 公开(公告)号 | HRP20192030T1 | 公开(公告)日 | |
| 申请(专利权)人 | JIANGSU HENGRUI MEDICINE CO | 发明人 | SUN PIAOYANG; WU GUAILI; ZHANG QUANLIANG; CHEN YONGJIANG; SHEN LINGJIA |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
The present invention relates to a crystal form of JAK kinase inhibitor bisulfate and a preparation method thereof. In particular, the present invention relates to a type II crystal of (3 aR, 5 s, 6 aS ) -N- (3-methoxyl-1, 2, 4-thiadiazole-5-yl)-5-(methyl(7 H- pyrrolo[2, 3- d ]pyrimi dine-4-yl)amino)hexahydrocyclopenta[ c ]pyrrole-2(1 H )-formamide bisulfate and a preparation method thereof. The preparation method comprises crystallizing any crystal forms or amorphous compound of formula (I) solid in a single organic solvent or a mixed organic solvent to obtain a type II crystal form of a compound of formula (I). The type II crystal form of compound of formula (I) obtained by the present invention has a good crystal stability and chemical stability, and the used crystal solvent has a low toxicity and residue, which can be better used in clinical treatment. |
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