The present invention concerns with new compositions containing lipophilic extracts of Piper nigrum, Zingiber officinale, Boswellia serrata and other plants used as adjuvant, prepared using as a solvent fluorinated hydrocarbons fluids in subcritical conditions. The compositions properly formulated are useful for topical and systemic treatment of pain and inflammation. The formulations are also active in muscle spasticity and neuropathic pains. The formulations according to the invention, exerting a powerful synergistic effect, are particularly useful in the treatment of osteoarthrosis, osteoarthritis and arthritis psoriatic pain alone or in combination with specific drugs. By topical application the formulation in form of creams, lotions or massage oils are indicated to reduce superficial and deep pain, edema and irritation of any origins.