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专利概况
专利名称 AN IMPROVED METHOD TO PRODUCE CHEMICAL COMPOUNDS DERIVED FROM OXALOACETATE BY MICROORGANISMS
申请号 WOEP19071358 申请日
公开(公告)号 WO2020030755A1 公开(公告)日
申请(专利权)人 TECHNISCHE UNIVERSIT腡 M躈CHEN 发明人 MARIN SANGUINO Alberto; PLF蹽ER GRAU Katharina; HOBMEIER Karina; KREMLING Andreas
专利来源 国家知识产权局 转化方式
摘要

A method for the production of a chemical compound derived from oxaloacetate using genetically modified microorganismsis disclosed. The chemical compound can for example be ectoine or the ectoine precursor NADA. The genetic modifications increase the compound production by increasing the extracellular accumulation, decreasing the intracellular degradation, and by disrupting the PEP-pyruvate-oxaloacetate node of the tricarboxylic acid(TCA) cycle. The microorganisms obtained by the genetic modifications are disclosed as well, as well as their use in the production method. The microorganisms are preferably gram negative bacteria, such as halophilic bacteria, for example Halomonas elongata.

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