The present invention provides bioactive serum fractions and bioactive extracts derived from an Achachairu (Garcinia humilis) plant. The bioactive serum fractions and bioactive extracts are free of or substantially free of benzophenone and/or free of or substantially free of proteins. The present invention also provides products comprising the bioactive serum fractions and/or bioactive extracts. The present invention further provides methods of making the bioactive serum fractions and/or bioactive extracts.