专利名称 | MULTIMERIZATION TECHNOLOGIES | ||
申请号 | RU2015143166 | 申请日 | |
公开(公告)号 | RU2714733C2 | 公开(公告)日 | |
申请(专利权)人 | МЕМОРИАЛ СЛОАН КЕТТЕРИНГ КЭНСЕР СЕНТЕР; MEMORIAL SLOAN KETTERING KENSER SENTER | 发明人 | АХМЕД Махиуддин; АХМЕД МахиуддинAKHMED Makhiuddin; ЧЕУНГ Най-Конг В.; ЧЕУНГ Най-Конг В.CHEUNG Naj-Kong V. |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
FIELD : medicine; pharmaceuticals.SUBSTANCE : present invention relates to immunology. Disclosed are a bispecific antibody and a fusion protein for specific binding to GD2 and CD3. Also disclosed are pharmaceutical compositions, nucleic acid, an expression vector, a host cell and a method of producing a bispecific antibody. Also described is a method of destroying neuroblastoma cells, a method of inhibiting growth of neuroblastoma and a method for increasing half-life of a bispecific antibody.EFFECT : present invention can find further application in increasing the activity of antibodies mobilizing T-cells for immunotherapy of malignant entities, particularly neuroblastoma.18 cl, 11 dwg, 19 tbl, 6 ex |
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