The present invention relates to a traditional Chinese medicine-magnetic nano-cluster chemical immunity drug delivery system and a preparation method therefor, comprising superparamagnetic oxide nanoparticles; a drug and a TAMs-targeting ligand are anchored to a surface of the superparamagnetic oxide nanoparticles; the superparamagnetic magnet oxide nanoparticles form a nanocluster structure by means of disulfide bonds; and the nanocluster structure is packaged by a protein. The traditional Chinese medicine-magnetic nano-cluster chemical immunity drug delivery system of the present invention integrates the targeting advantages of magnetic trending, ligand modification, and reduction sensitivity, and is a traditional Chinese medicine chemical immunity drug delivery system having stable internal circulation, highly efficient tumor accumulation and precise TAMs targeting.